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KMID : 1098420070150020132
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Korean Journal of Medicinal Crop Science
2007 Volume.15 No. 2 p.132 ~ p.137
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Inhibitory Effect of Scutellaria baicalensis Root Extract on Chemical Mediator Release and Immune Response
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Lim Byong-Ou
Choi Se-Young
Choi Dong-Kug
Park Pyo-Jam
Choi Wahn-Soo
Kim Jong-Dai
Shin Heung-Mook
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Abstract
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Inhibitory effect of Scutellaria baicalensis ethanol extracts (SR) on chemical mediator release and immunoglobulin (Ig) production from Sprague-Dawley rats originated cells as type I allergic reaction was examined. SR showed concentration-dependent inhibition on basal and concanavalin A (ConA)-stimulated Ig production. In the mesenteric lymph node lymphocytes, the inhibitory effect of SR on the IgE production in the presence of Con A was stronger than these on IgA and IgG production. Moreover, tumor necrosis factor-alpha production-inhibiting effect of SR in the presence ConA was observed. However, SR did not affect the production of . SR also inhibited histamine release from the peritoneal exudate cells stimulated with a calcium ionophore A23187. In the case of leukotriene B4, SR markedly inhibited it at the concentration of 100 mg/ml. From these results, ethanol extracts obtained from Scutellaria baicalensis may have an anti-allergic effect on the intestinal system of rats.
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KEYWORD
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Scutellaria baicalensis ethanol extract (SR), chemical mediators, Ig production, , allergy
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